HORDB

ID: hor005313
Uniprot ID: P0CJ22
Protein name: Neuropeptide Y1-like conopeptide
Gene name: NA
Organism: Conus betulinus (Beech cone)
Family: NPY family
Source: animal
Expression: Expressed by the venom duct.
Disease: NA
Comments: NA
Taxonomy: Dendroconus (subgenus), Conus (genus), Conidae (family), Conoidea (superfamily), Neogastropoda (order), Caenogastropoda (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity; GO:0090729 toxin activity
GO BP: GO:0007165 signal transduction; GO:0035821 modulation of process of another organism
GO CC: GO:0005576 extracellular region

Function: Causes hyperactivity such as jumping, rapid circling and tail flicking, when intraventricularly injected into mice brain.
Mechanism: The mature peptide does not contain cysteine residue.
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-P0CJ22-F1.pdb

hor005313_AF2.pdb

hor005313_ESM.pdb

Mass:	503429	Formula:	C198H305N59O53S
Absent amino acids:	CKQW	Common amino acids:	R
pI:	10.11	Basic residues:	7
Polar residues:	8	Hydrophobic residues:	13
Hydrophobicity:	-49.46	Boman Index:	-9768
Half-Life:	7.2 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	71.08
Instability Index:	4110.81	Extinction Coefficient cystines:	2980
Absorbance 280nm:	82.78

PubMed ID: 20705590
Title: Identification of neuropeptide Y-like conopeptides from the venom of Conus betulinus.